PT-141 [10mg]

PT-141 [10mg]

$65.00

PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and analog of alpha-melanocyte-stimulating hormone (α-MSH), originally derived from the melanocortin agonist Melanotan II. It is classified in research literature as a non-selective melanocortin receptor agonist with primary interest in MC4R-mediated signaling.

Researchers investigate PT-141 for:

  • Melanocortin receptor (MC3R/MC4R) signaling mechanisms
  • Central nervous system arousal and motivation pathways
  • Hemodynamic and blood pressure modulation models
  • Neuroinflammatory and cytokine expression studies
  • Receptor-binding and agonist activity characterization

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SKU: PT141 Category:

Description

PT-141 [10mg]

Chemical Identity & Molecular Composition

Chemical Name: Bremelanotide (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH)

Chemical Class: Synthetic cyclic heptapeptide, α-MSH analog, melanocortin receptor agonist

Molecular Formula: C₅₀H₆₈N₁₄O₁₀

Molecular Weight: ~1025.2 g/mol

CAS Number: 189691-06-3

Structural Characteristics

PT-141 is a synthetic cyclic heptapeptide derived from the melanocortin agonist Melanotan II. “The cyclic lactam structure and substitution of the C-terminal amide with a carboxyl group increase metabolic stability while preserving melanocortin receptor binding affinity.” Unlike its precursor, the modified structure shifts receptor activity away from pigmentary pathways and toward central melanocortin signaling.

The peptide is supplied as a lyophilized white powder with purity ≥98% (HPLC). It is water-soluble and demonstrates stability in physiological conditions. The compound acts as a non-selective agonist across MC1R, MC3R, MC4R, and MC5R, with research interest centered on MC4R-mediated signaling.

Research Applications

Melanocortin Receptor Research: PT-141 is studied as a non-selective melanocortin agonist for characterizing MC3R and MC4R signaling pathways in receptor-binding investigations.

Neurobehavioral Studies: Preclinical research examines central MC4R activation and its role in arousal and motivation pathways within the central nervous system.

Cardiovascular Modeling: In vivo studies investigate hemodynamic responses and transient blood pressure modulation associated with melanocortin pathway activation.

Immunomodulatory Research: Emerging research explores melanocortin-mediated effects on inflammatory cascades and cytokine expression in neuroimmune models.

Storage & Handling

“Store lyophilized peptide at -20°C, protected from light and moisture. Reconstitute with bacteriostatic water; store at 2-8°C and use within 21 days.”

Disclaimer

This product is intended for laboratory research use only. It is not intended for human consumption, medical, therapeutic, or diagnostic use. All handling and use must comply with applicable laws and regulations.

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