Tesamorelin [10mg]

Description

Chemical Identity & Molecular Composition

Chemical Name: Tesamorelin Acetate ({trans-3-hexenoic acid}-GHRH(1-44)-NH₂)
Chemical Class: Modified GHRH analog
Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight: ~5135.6 g/mol
CAS Number: 218949-48-5

Structural Characteristics

Tesamorelin is a 44-amino acid synthetic peptide identical to human GHRH(1-44) with a trans-3-hexenoic acid group conjugated to the tyrosine at position 1 via the amino terminus. This lipophilic modification improves metabolic stability and extends the half-life compared to native GHRH while maintaining full agonist activity at the GHRH receptor.

The peptide is supplied as a lyophilized acetate salt with purity ≥98% (HPLC). It is reconstitutable in sterile water. The trans-3-hexenoic acid modification is key to its enhanced pharmacokinetic profile, providing resistance to DPP-IV enzymatic cleavage that rapidly degrades native GHRH.

Research Applications

Growth Hormone Axis Research: Tesamorelin provides researchers with a stabilized GHRH agonist for studying pulsatile GH release patterns, somatotroph cell function, and hypothalamic-pituitary axis regulation in preclinical models.

Visceral Adiposity Studies: Research extensively examines Tesamorelin’s effects on visceral adipose tissue (VAT) reduction, investigating the mechanisms by which enhanced GH signaling influences lipid mobilization and adipocyte metabolism.

Hepatic Fat Research: Preclinical and clinical studies explore Tesamorelin’s effects on hepatic steatosis and non-alcoholic fatty liver disease (NAFLD) markers, examining the relationship between GH stimulation and liver fat metabolism.

Cognitive Research: Emerging studies investigate Tesamorelin’s effects on cognitive function in aging models, exploring the relationship between restored GH pulsatility and neurological outcomes including executive function and memory.

Storage & Handling

Store lyophilized peptide at -20°C, protected from light and moisture. Reconstitute with sterile water; store at 2-8°C and use within 14 days. Do not freeze after reconstitution.

Disclaimer

This product is intended for laboratory research use only. It is not intended for human consumption, medical, therapeutic, or diagnostic use. All handling and use must comply with applicable laws and regulations.