Sermorelin [10mg]

Description

Chemical Identity & Molecular Composition

Chemical Name: Sermorelin Acetate (GRF 1-29 NH₂)
Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight: ~3357.9 g/mol
CAS Number: 86168-78-7

Structural Characteristics

Sermorelin is a 29-amino acid peptide amide representing the biologically active N-terminal segment of endogenous GHRH(1-44). This truncated form retains full agonist activity at the GHRH receptor (GHRH-R) while offering improved synthesis efficiency and research versatility. The C-terminal amidation enhances receptor binding stability.

Sermorelin is supplied as a lyophilized acetate salt with purity ≥98% by HPLC. It is freely soluble in water and dilute acidic buffers. The peptide acts specifically on somatotroph cells in the anterior pituitary, making it a valuable tool for GH axis research without directly elevating IGF-1 independent of physiological feedback.

Research Applications

Growth Hormone Axis Studies: Sermorelin is extensively used in preclinical research examining GHRH receptor signaling, pulsatile GH release patterns, and the hypothalamic-pituitary-somatotroph axis. It serves as a standard GHRH receptor agonist in comparative secretagogue studies.

Aging & Somatopause Research: Researchers use Sermorelin to investigate age-related decline in GH secretion, examining whether GHRH receptor sensitivity changes with aging and how restored GH pulsatility affects various physiological parameters in aged animal models.

Metabolic Studies: Preclinical research explores the downstream metabolic effects of physiological GH stimulation, including lipid metabolism, glucose homeostasis, and lean mass parameters.

Sleep & Circadian Research: Studies have examined Sermorelin’s effects on slow-wave sleep architecture, as GHRH is known to play a role in sleep regulation independent of its GH-releasing function.

Storage & Handling

Store lyophilized peptide at -20°C, protected from light and moisture. Once reconstituted with bacteriostatic water, store at 2-8°C and use within 21 days. Avoid repeated freeze-thaw cycles.

Disclaimer

This product is intended for laboratory research use only. It is not intended for human consumption, medical, therapeutic, or diagnostic use. All handling and use must comply with applicable laws and regulations.